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JWH-018 powder and liquid for sale Belarus. You can order JWH-018 powder and liquid . Low Price. Purchase JWH-018 powder and liquid Belarus. Best JWH-018 powder online without prescription.JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678^[1] is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with some selectivity for CB₂. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as “incense blends”.^{[2][3][4][5][6]}

As a full agonist at both the CB₁ and CB₂ cannabinoid receptors, this chemical compound is classified as an analgesic medication.^[7] The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis.

These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling.^[7] As the cause is poorly understood in chronic pain states, more research and development must be done before the therapeutic potential of this class of biologic compounds can be realized

JWH-018 powder and liquid for sale Belarus |Buy JWH-018 powder

JWH-018 is a full agonist of both the CB₁ and CB₂ cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB₁ and 2.94 ± 2.65 nM at CB₂. JWH-018 has an EC₅₀ of 102 nM for human CB₁ receptors, and 133 nM for human CB₂ receptors. JWH-018 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity.